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G6PD Deficiency • Glucose-6-phosphate dehydrogenase deficiency • X-linked recessive disorder • Leads to low NADPH, impairing glutathione regeneration → RBCs are vulnerable to oxidative damage ⸻ Pathophysiology: In G6PD deficiency: • No

Unlike nuclear DNA, mtDNA lacks protective histones and has limited repair capacity, making it more susceptible to oxidative damage and mutation

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Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: Localization, expression and participation in neurodegenerative diseases

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